Olaparib clinical trials

Clinical trials of chemotherapeutics in combination with PARP inhibitors demonstrated the PFS benefit of the concurrent and sequential combination of olaparib with platinum-based chemotherapy compared with that of platinum-based chemotherapy alone and showed that the benefits are mainly. Please note - unless we state otherwise in the summary. Clinical Trials Using Olaparib - National Cancer Institute Clinical trials are research studies that involve people.

Maintenance Olaparib in Ovarian Cancer with Mutant BRCA Among women with advanced ovarian cancer with a BRCA mutation who had a response after platinum-based therapy, the. Olaparib - National Cancer Institute Find Clinical Trials for Olaparib - Check for trials from NCIaposs list of cancer clinical trials now accepting patients. Enrollment to the olaparib monotherapy arm will be completed prior to commencement of enrollment to the olaparib and AZD67arm). This site is part of our commitment to provide patients and healthcare professionals with meaningful information about AstraZeneca medicines and drugs in development. Phase trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market.

Phase trials are small trials that help researchers decide if a new agent should be tested in a phase trial. May 1 20Critical ongoing trials of olaparib in ovarian cancer.

Jan 1 20Clinical benefit rate (CBR) for olaparib in combination with durvalumab Time Frame: Up to months post treatment An estimate of CBR will be measured and reported with exact confidence interval. NCIs basic information about clinical trials explains the types and phases of trials and how they are carried out. Gov Patients with tumors harboring damaging mutations in Homologous - DNA repair (HDR) genes or mutations such as ATM, CHK MRN (MRE11NBS1RADCDKN 2AB and APOBEC will be treated with olaparib or olaparib and AZD6738. Important: The drug information on this page is meant to be educational. AstraZeneca Clinical Trials Website This web site provides clinical trial data, and other information from or regarding AstraZeneca-sponsored clinical trials.

Participants who achieve a CR, Pr, or stable disease (SD) for at least months on the current protocol will be qualified as deriving benefit. There are also less common very early (phase 0) and later (phase 4) phases. To evaluate the antitumour activity of olaparib against metastatic castration-resistant prostate cancer, we designed TOPARP, an adaptive programme of serial phase clinical trials aimed at identifying predictive biomarkers for response to PARP inhibition in metastatic castration-resistant prostate cancer. This trial is comparing olaparib and chemotherapy to chemotherapy alone for triple negative breast cancer or breast cancer with a change in the BRCA gene.

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